Down regulation of gene activity associated with the innate immune pathways.

<p>Commercial PCR arrays were used. Fold decrease was calculated by comparing data obtained with αA−/− EAU without αA treatment and αA−/− EAU mice treated with αA. A = Toll like receptors B = associated adaptive and signaling proteins and C = the NFkB pathway in αA−/− mice with EAU treated with αA. TLRs = Toll like receptors, MyD88: Myeloid differentiation primary response gene (88), Irak1 = Interleukin-1 receptor-associated kinase 1, CD14 = Cluster of differentiation 14, Ticam 2 = TIR domain-containing adapter molecule 2, Tirap = toll-interleukin 1 receptor (TIR) domain containing adaptor protein, Cox-2 = Cyclooxygenase-2, Irf-1 = Interferon regulatory factor 1, IL-1R1 = Interleukin 1 receptor, type I, Il-6re = IL6 responsive element, Map3K1 = Mitogen-activated protein kinase kinase kinase 1, NFkB = Nuclear factor kappa B, Ccl2 = Chemokine (C-C motif) ligand 2, IFN-γ = Interferon-gamma.