Crystal structure of Mal-TIR.

<p>(<b>A</b>) Schematic illustration of five TIR-domain-containing adaptors involved in TLR signaling. Mal: MyD88 adaptor-like protein; MyD88: myeloid differentiation factor 88; TRIF: TIR-domain-containing adaptor-inducing interferon-β; TRAM: TRIF-related adaptor molecule; SARM: sterile and HEAT/armadillo (ARM) motif protein; DD: death domain; ID: intermediate domain; SAM: sterile α-motif. (<b>B</b>) Cartoon representation of the structure of Mal-TIR. The β-strands are shown in pink, the α-helices in cyan and the connecting loops in salmon. The AB loop is colored red. The red dotted line represents the region that is not resolved in this structure.