Results from a probe trial intended to measure spatial memory.

<p>Percentage of time spent searching in the former location of the platform (Target Quad) in (A) males and (B) females, compared to time spent in the adjacent quads. Aspartame-fed males showed a reduction in the number of times they crossed over former location of the platform (C: Platform Crossings and (E: Annulus Crossing Index), n = 12 per group, * P<0.05, ** P<0.01, *** P<0.001. There was no significance in the reduction of platform crossings and Annulus Crossing Index in females. Actual overlapping swim paths of the control (G,I) and aspartame-fed mice (H,J). Swim paths illustrate less intense swimming in the location of the platform by aspartame-fed mice, compared to controls.