Comparing skew and mean replication timing (MRT).

<p>(A) profile along a 11.4 Mb long fragment of human chromosome 10 that contains 6 skew N-domains (horizontal black bars) bordered by 7 putative replication origins to . Each dot corresponds to the skew calculated for a window of 1 kb of repeat-masked sequence. The colors correspond to intergenic (black), genes (red) and genes (blue). (B) Corresponding cumulative skew profile obtained by cumulative addition of -values along the sequence. (C) MRT profiles from early, 0 to late, 1 for BG02 (green), K562 (red) and GM06990 (blue) cell lines. (D) Correlations between and , in BG02 (100 kb windows) along the 22 human autosomes; colors as in (A); the corresponding Pearson correlations are given in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002443#pcbi-1002443-t001" target="_blank">Table 1</a>. (E) Average profiles ( SEM) in the 663 skew N-domains after rescaling their length L to unity; colors as in (C).