Phenotypic variance explained by genotypic variation.

<p>(<b>A</b>) Total explained variance for genetically controlled parameters (x axis) using detected causal SNPs as predictors. (<b>B</b>) Total explained variance for cellular phenotypes (x axis) using detected causal SNPs obtained from GWAS targeting these phenotypes. (<b>C</b>) Total explained variance for cellular phenotypes (x axis) using detected causal SNPs obtained from GWAS targeting all genetically controlled parameters. Each boxplot summarizes total explained variance by GWAS for 100 Monte Carlo runs. Explained variance was measured as R² from test set prediction with a multiple regression model, see <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002459#s2" target="_blank">Methods</a> for further descriptions.