<p>Less-than-additive and greater-than-additive effects are caused by three-body-interactions between RNA polymerase and two transcription factor molecules of the same type bound at two different promoter sites. Two-body-interactions between the two transcription factor molecules are assumed to be negligible. The function is shown (solid line). The dashed line indicates the asymptote of the solid line.</p
<p>We vary two key parameter values (keeping the rest fixed at the values shown in <a href="http://w...
The Hill coefficient is often used as a direct measure of the cooperativity of binding processes. It...
Expression levels of most genes are proportional to cell volumes, although some genes exhibit nonlin...
<p><b>-</b><b> for </b><b> and </b><b> responses to strong activations.</b> Cooperative effects are ...
<p>Parameter space - is considered here. Cooperative effects are caused by the nonlinearity of the R...
<p>Cooperative effects are caused by the nonlinearity of the RNA polymerase binding probability func...
We derive a statistical model of transcriptional activation using equilibrium thermodynamics of chem...
<p>Additive effect and p-value of the SNPs representing the top trio of transcription factors.</p
<p>The thermostatistical model of transcription initiation predicts different dose response patterns...
<p>Bars labeled ‘D’ represent the magnitude of a reported greater-than-additive effect. Panels A–B, ...
<p>For rescaled activator concentrations and corresponding to a point ‘above’ (‘below’) the hyperb...
<p>The function was computed from Eqs. (15,18) for the transcription factor impact . The transcript...
<p><i>A model</i>. Solid lines represent interactions suggested by results (line thickness is propor...
Transcriptional interference is the in cis suppression of one transcriptional process by another. Ma...
Figures in the first column: schematic of the experiment 2: comparison of the expression ranges of r...
<p>We vary two key parameter values (keeping the rest fixed at the values shown in <a href="http://w...
The Hill coefficient is often used as a direct measure of the cooperativity of binding processes. It...
Expression levels of most genes are proportional to cell volumes, although some genes exhibit nonlin...
<p><b>-</b><b> for </b><b> and </b><b> responses to strong activations.</b> Cooperative effects are ...
<p>Parameter space - is considered here. Cooperative effects are caused by the nonlinearity of the R...
<p>Cooperative effects are caused by the nonlinearity of the RNA polymerase binding probability func...
We derive a statistical model of transcriptional activation using equilibrium thermodynamics of chem...
<p>Additive effect and p-value of the SNPs representing the top trio of transcription factors.</p
<p>The thermostatistical model of transcription initiation predicts different dose response patterns...
<p>Bars labeled ‘D’ represent the magnitude of a reported greater-than-additive effect. Panels A–B, ...
<p>For rescaled activator concentrations and corresponding to a point ‘above’ (‘below’) the hyperb...
<p>The function was computed from Eqs. (15,18) for the transcription factor impact . The transcript...
<p><i>A model</i>. Solid lines represent interactions suggested by results (line thickness is propor...
Transcriptional interference is the in cis suppression of one transcriptional process by another. Ma...
Figures in the first column: schematic of the experiment 2: comparison of the expression ranges of r...
<p>We vary two key parameter values (keeping the rest fixed at the values shown in <a href="http://w...
The Hill coefficient is often used as a direct measure of the cooperativity of binding processes. It...
Expression levels of most genes are proportional to cell volumes, although some genes exhibit nonlin...