Age-related cortical bone loss in male TTD mice.

<p>Cortical bone parameters (A-D) were studied in aging wild type (solid) and TTD (open) tibial diaphyses.(A) Cortical thickness (Ct.Th.), (B) cortical volume (Ct.V.), (C) endocortical volume (Ec.V.), (D) 3D thickness distribution. Figures E and F depict the significant decrease in cortical thickness when comparing 26 week old wild type (E) and TTD (F) mice. Statistics: a= student t-test; p<0.05 wild type vs. TTD, b−d = 2 way ANOVA; p<0.05. b= significant difference between wild type and TTD with aging, c= signifcant difference with aging within a genotype, d= a significant interaction between age and genotype. Error bars represent SEM.