Rearrangement of the astroglial network in a mouse model of mesiotemporal lobe epilepsy.

<p><b>A–B</b>) Bright field microscopy imaging (Nikon Multizoom AZ100, France) of acute hippocampal slices from adult mice 2 weeks after a unilateral intrahippocampal kainate injection. <b>A</b>) Contralateral non-injected hippocampus. <b>B</b>) Ipsilateral hippocampus. Note the absence of CA1/CA3 areas and the enlargement of the dentate gyrus. <b>C–D</b>) TPLSM imaging of regions indicated by white squares on (A) and (B) images, respectively, after iv injection of SR101. Scale bar = 50 µm. <b>E</b>) Column scatters representation showing the distribution of astrocytes cell body volumes at both sides of the hippocampus. The bar corresponds to the mean value.