Schematic representation of multi-drug resistance regions of pGUE-NDM, pC15-1a and pEK516 incFII plasmids.

<p>The genes and their corresponding transcriptional orientations are indicated by horizontal arrows. Function of each genes are indicated by colored arrows as follows: green, tetracycline resistance; azure, β-lactams resistance genes; orange, aminoglycosides resistance genes; dark green, trimethoprim resistance gene. Transposon-related genes and insertion sequences are indicated in red arrows. Class 1 integrase gene is indicated by black arrow. Deletion is indicated by blue dashed lines. Homologous recombination event leading to inversion is indicated by black dashed lines. Homologous recombination event leading to allelic exchange of <i>bla</i>_CTX-M-15 locus by <i>bla</i>_NDM-1 locus is indicated by red dashed lines. The accession numbers were: pC15-1a (genbank n°AY458016) and pEK516 (genbank n°EU935738).