Differential risk allele frequencies in the East Asian populations for 12 common diseases, compared with the frequencies in the European.

<p>We identified 12 common diseases with five or more independent cross-ethnic risk alleles from Varimed. Similar with <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1002621#pgen-1002621-g003" target="_blank">Figure 3</a>, we plotted the average increased RAFs in the East Asia regions in the HGDP for each of 12 diseases, against the null distributions of frequency-matched control genomic alleles and risk alleles for other diseases. We ordered these 12 diseases by the increased RAF for a direct comparison. T2D was the only disease showing significantly lower RAFs in the East Asian populations. Two-side p values were calculated by comparing dotted vertical lines against the null distributions of frequency-matched control genomic alleles and risk alleles of other diseases. SNPs used in each figure were summarized in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1002621#pgen.1002621.s011" target="_blank">Table S4</a>.