Distribution of T2D Genetic Risk Scores in 1,397 HapMap3 individuals.

<p>A high T2D Genetic Risk Score (GRS) had been previously shown to significantly associate with increased risk of developing diabetes in participants from Diabetes Prevention Program <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1002621#pgen.1002621-Hivert1" target="_blank">[19]</a>. We calculated the GRS scores for 1,397 individuals using 20 SNPs measured in the HapMap and plotted the distribution of GRS across 11 HapMap populations. The distribution of GRS is very similar with that of PGR in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1002621#pgen-1002621-g006" target="_blank">Figure 6A</a>. p_Asi, p_Eur, and p_Afr represent the likelihoods of observing more extreme values of log(GRS, Asian)-log(GRS, Other), log(GRS, European)-log(GRS, others), and log(GRS, African)-log(GRS, Other) using randomly selected control genomic genotypes, respectively. All p values were calculated as two-sided p values. GRS SNPs were summarized in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1002621#pgen.1002621.s011" target="_blank">Table S4</a>.