Synthetic Cl⁻ channel formed by compound 1 restored cell Cl⁻ permeability in CF cells.

<p>(<b>a</b>) Representative traces showing whole-cell currents in CF cells. The left panel shows the stimulation protocol for whole-cell recording, and the middle panel shows DMSO control currents. The right panel shows whole-cell currents after the application of 1 µM compound <b>1</b>. (<b>b</b>) The current–voltage relationships obtained in the absence (○) and presence (•) of 1 µM compound <b>1</b> and after washout (▴) with the control bath solution for 30 min in CuFi-8 cells. (<b>c</b>) Summary of whole-cell currents at ±80 mV induced by forskolin (2 µM) and compound <b>1</b> (1 µM) in CuFi-8 and NuLi-1 cells. All data are means ± s.e. n = 5–6.