Influence of vector configuration and route of vaccination.

<p>Groups of mice were either vaccinated with Ad5-IiOva or left untreated. Two months later, mice from both groups were vaccinated i.m. or s.c. with Ad5-IiGP or Ad5-GP, and the transgene-specific CD8 T-cell response was evaluated. Results for GP276 in mice vaccinated with Ad5-GP have not been not been included as this vector construct does not cause a clearly detectable CD8 T-cell response even in vector-naïve mice. Dotted lines denote limit of detection for IFN-γ⁺ CD8 T cells as determined by analysis of unstimulated cells.