IL-7 regulates CD98 expression levels in vitro and in vivo.

<p>CD8⁺ T cells from C57Bl6/J mice were either cultured <i>in vitro</i> in the presence or absence of IL-7 for 24 h, or transferred to either <i>Rag1</i>^−/− or <i>Il7</i>^−/−<i>Rag1</i>^−/− hosts. Upper histograms show CD98 expression by CD44^loCD8⁺ cells cultured for 24 h either alone (red line) or in the presence of 50 ng/ml IL-7 (black line) as compared with <i>ex vivo</i> control CD44^loCD8⁺ T cells (grey fill). Lower histograms show CD98 expression in CD44^loCD8⁺ cells transferred to <i>Rag1^−/−</i> (black line) or <i>Il7^−/− Rag1^−/−</i> hosts (red line) for 3 days, as compared with <i>ex vivo</i> control CD44^loCD8⁺ T cells (grey fill). Results are representative of three independent experiments.