<p>Distributions of left and right breakpoints of aging-associated mtDNA deletions and of left and right DR motifs from (A) human, (B) rhesus monkey, (C) mouse and (D) rat. Standard deviation (error bars) for the frequency of breakpoints in each bin is calculated based on a binomial distribution.</p
<p>(A) DNA from young (1 month, n = 8) and old (18 months, n = 8) mice were analyzed for mutation ra...
<p>Del, deletion. The median number of pack-years of combined cases and controls was utilized as the...
<p>(A) Bar graphs representing changes in mean heteroplasmy of early embryonic mutations with <i>Pol...
Deletion mutations within mitochondrial DNA (mtDNA) have been implicated in degenerative and aging r...
<div><p>Deletion mutations within mitochondrial DNA (mtDNA) have been implicated in degenerative and...
<p>Resolution of DR distribution based on DR free energy and position in mtDNA sequence of (A) human...
<p>(A) Frequency of the common deletion per mtDNA (mtDNA<sup>−1</sup>), (B) Major-arc deletions, (C)...
<p>(A) Sequence logo of the degenerate 11-mer motif over-represented in the close vicinity (±15 bp) ...
<p>Accumulation of mtDNA with deletions (average of deletions at the segments encoded for CYTB, COX3...
<p>Bars depict mtDNA copy number per cell from mice aged four months. Tissues analyzed included brai...
<p>Abundance, distribution and free energy of DRs in mtDNA and random DNA sequences (<i>n</i> = 100)...
<p>The X-axis indicates the exon intervals for breakpoints across the <i>DMD</i> gene. The Y-axis re...
<p>(A) Breakpoints in deletions. (B) Breakpoints in duplications. 5’ breakpoints in grey and 3’ brea...
<p>Del, deletion.</p><p>For multiple comparisons, <i>p</i> value was set <0.05/2×(n−1) (n = 8).</p>a...
<p>Independent values for the difference in deletion level (in percentage points) between two homoge...
<p>(A) DNA from young (1 month, n = 8) and old (18 months, n = 8) mice were analyzed for mutation ra...
<p>Del, deletion. The median number of pack-years of combined cases and controls was utilized as the...
<p>(A) Bar graphs representing changes in mean heteroplasmy of early embryonic mutations with <i>Pol...
Deletion mutations within mitochondrial DNA (mtDNA) have been implicated in degenerative and aging r...
<div><p>Deletion mutations within mitochondrial DNA (mtDNA) have been implicated in degenerative and...
<p>Resolution of DR distribution based on DR free energy and position in mtDNA sequence of (A) human...
<p>(A) Frequency of the common deletion per mtDNA (mtDNA<sup>−1</sup>), (B) Major-arc deletions, (C)...
<p>(A) Sequence logo of the degenerate 11-mer motif over-represented in the close vicinity (±15 bp) ...
<p>Accumulation of mtDNA with deletions (average of deletions at the segments encoded for CYTB, COX3...
<p>Bars depict mtDNA copy number per cell from mice aged four months. Tissues analyzed included brai...
<p>Abundance, distribution and free energy of DRs in mtDNA and random DNA sequences (<i>n</i> = 100)...
<p>The X-axis indicates the exon intervals for breakpoints across the <i>DMD</i> gene. The Y-axis re...
<p>(A) Breakpoints in deletions. (B) Breakpoints in duplications. 5’ breakpoints in grey and 3’ brea...
<p>Del, deletion.</p><p>For multiple comparisons, <i>p</i> value was set <0.05/2×(n−1) (n = 8).</p>a...
<p>Independent values for the difference in deletion level (in percentage points) between two homoge...
<p>(A) DNA from young (1 month, n = 8) and old (18 months, n = 8) mice were analyzed for mutation ra...
<p>Del, deletion. The median number of pack-years of combined cases and controls was utilized as the...
<p>(A) Bar graphs representing changes in mean heteroplasmy of early embryonic mutations with <i>Pol...
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