PS at distal or proximal inputs bidirectionally regulate the ISI of spike bursts.

<p>(A) Schematic of experimental configuration. The TBS was delivered to distal inputs to GCs in the EPL. (B) Representative traces of spike bursts evoked by current injections under conditions with or without prior stimulation. Top, without prior stimulation, the ISI of spike bursts failed to display any obvious changes 20 min later (control). Bottom, ISI was shortened 20 min after prior stimulation at distal inputs to GCs (primed), which was at the exact time-point of STDP induction. (C) Schematic of the experimental configuration. The TBS was delivered to proximal inputs to GCs at the GCL. (D) Representative traces of spike bursts evoked by current injection under conditions with or without prior stimulation. Bottom, the ISI was prolonged 20 min after prior stimulation at proximal inputs to GCs. (E) Summary of changes in the ISI of spike bursts under various conditions. ** <i>p</i><0.01, compared between indicated groups.