Ruthenium- and Copper-Catalyzed Enantioselective Propargylic Alkylation of Propargylic Alcohols with β-Keto Phosphonates

The enantioselective propargylic alkylation of propargylic alcohols with β-keto phosphonates in the presence of a thiolate-bridged diruthenium complex and a copper complex as cocatalysts gives the corresponding propargylic alkylated products in excellent yields with high diastereo- and enantioselectivities (up to 97% ee)