Combined profiling data for the 52 differentially expressed proteins.

<p>The venn diagramm shows the distribution of individually and shared proteins as defined by 2-DE-based proteomic profilings in response to the indicated stimulation conditions. Proteins that are either shared in response to CD3 and CD28 or CD3/IL2 and CD3/CD28 are listed next to the connecting lines. Proteins defined via silver staining are listed in plain, proteins defined by DIGE-analysis in bold. The relative regulation mode for the given protein if compared to its expression level in unstimulated T cells is indicated by arrows. Arrows pointing up indicate increased expression levels in response to stimulation, whereas downregulated proteins after flanked by arrows pointing down.