Effect of a pan-caspase inhibitor (zVAD-fmk) and a specific caspase-8 inhibitor (zIETD-fmk) on the induction of apoptosis by LBW242 (LBW) or TRAIL or both agents.

<p>A2780WT, A2780FLIP, A2780ADR, A2780ADR FLIP, SKOV3 and SKOV3 FLIP cells have been grown as reported in Fig. 2 either in the absence or in the presence of 40 μM zVAD-fmk or zIETD-fmk and after 48 h of incubation the percentage of apoptotic cells was determined by Annexin-V/PI binding assay. The results represent mean values ± SEM observed in three separate experiments.