Changes in correlation of HLA risk with Treg apoptosis and Treg function in subject cohorts representing stages of T1D development.

<p>In High HLA risk both healthy control and LS T1D subjects, increased Treg apoptosis significantly correlated with increased Treg function (p = 0.017 and p = 0.042, respectively). High HLA risk RO T1D subjects showed opposite correlation: increased Treg apoptosis was correlated with decreased Treg function (p = 0.027). Multiple Ab+ subjects did not show correlation between Treg apoptosis and function in High HLA risk group (p = 0.95). Although some trends were present, Low HLA risk groups did not show correlation with Treg apoptosis and function.