Differential gene expression in the three subject groups relative to Low HLA risk group.

<p>Ratio of gene expression between Tregs and CD25− from each subject was first obtained and averaged for each group before comparison to the Low HLA risk control subject group. A) fold change genes expression in the High HLA risk healthy control (n = 8), Ab+ subjects (n = 4), RO T1D subjects (n = 4), relative to Low HLA risk subject group (n = 5), B) fold change of genes uniquely expressed in RO T1D (red bars), Ab+ subjects (dark grey bars) and High HLA risk subjects (light grey bars) relative to Low HLA risk group. C) Genes downregulated in High HLA risk group compared to Low HLA risk group. Cutoff value for presentation of overexpressed genes was >5-fold. * - anti-apoptotic genes.