Caspase-1 is not required for innate host protection against <i>Yersinia</i> endowed with enhanced cytotoxicity.

<p>(A) Six to eight-week old Casp1<i>^+/+</i> (wild type, WT) or Casp1<i>^−/−</i> (Casp1-) C57BL/6J mice were infected orogastrically with 1×10⁹ CFU of <i>Y. pseudotuberculosis</i> IP26 carrying pACYC184 encoding YopP or YopJ^YPTB. Mouse survival was monitored for 21 days. Results shown are pooled from two independent experiments. Total numbers of mice infected are shown in parenthesis. (B) Data from (A) are reformatted by grouping mice according to infecting strain. Significant difference between survival curves was determined by log rank test.