TIMP-1-GPI promotes wound healing <i>in vitro.</i>

<p>A monolayer of human primary mesothelial cells was cultured with an experimental wound model insert provided by Ibidi GmbH (Munich, Germany). Removal of the insert yielded a uniform “wound” to the monolayer. (<b>A</b>) Treatment with TIMP-1-GPI but not the control proteins, showed a dose dependent increase in wound closure. (<b>B</b>) The closing areas were calculated using imaging software NIS-Elements. (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0033963#pone.0033963.s003" target="_blank">Video S1</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0033963#pone.0033963.s004" target="_blank">S2</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0033963#pone.0033963.s005" target="_blank">S3</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0033963#pone.0033963.s006" target="_blank">S4</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0033963#pone.0033963.s007" target="_blank">S5</a>).