SD-OCT images of WT and Retinitis Pigmentosa (RP) rabbit retinas and histology of the visual streak in an RP rabbit.

<p>(A) A fundus infrared image of a WT rabbit retina, including optic nerve head (ONH) and visual streak. The area between dotted lines is the visual streak. (B) A vertical SD-OCT image along the green arrow in panel A, which passes through the center of the ONH. On this vertical image, the scleral ring was regarded as the lower margin of the ONH. (C) A magnified OCT image of the area enclosed by the blue square in panel B, which includes the visual streak. (D) A fundus infrared image of a RP rabbit retina, including the ONH and visual streak. (E) A vertical SD-OCT image of a 20-week-old RP rabbit along the green arrow in panel D. (F) A magnified OCT image of the area enclosed by the blue square in panel E. The 2.2 mm width of this OCT section was vertically cut between 1.8 mm and 4.0 mm ventral to the inferior edge of the ONH. A dotted arrow indicates the region of the visual streak. (G) Hematoxylin-Eosin staining of a retinal section corresponding to the area in the OCT image in F. Scale Bar = 200 µm (B, E), 100 µm (C, F), and 50 µm (G). RNFL, retinal nerve fiber layer; GCL, ganglion cell layer; IPL, inner plexiform layer; GCC, ganglion cell complex; INL, inner nuclear layer; OPL, outer plexiform layer; ONL, outer nuclear layer; ELM, external limiting membrane; IS, inner segments of photoreceptors; OS, outer segments of photoreceptors; IS/OS, junctions between IS and OS; RPE, retinal pigment epithelium; and BM, Bruch's membrane.