Selective reduction of depolarization-induced stress in Dicer KO bladder.

<p>Panel A shows original force records of control (black line) and Dicer KO (gray line) bladder strips. Following contraction in response to 60 mM K⁺ (HK) and relaxation, 3 mM ATP was added every 10 min. The preparations were washed three times following each ATP challenge. Insets show representative ATP responses on an expanded time scale (n = 4–7). B and C show summarized data for the peak ATP- and α,β-methylene-ATP-induced stress in control (black bar) and Dicer KO (white bar) bladders. Panel D shows cumulative concentration-response relationship for carbachol for control and Dicer KO bladders (n = 10–11).