<p><b>A.</b> Representative images of neurospheres from normal human neural stem cell lines 1–3 (NSC1–3) and glioblastoma stem cell lines 1–3 (GSC1–3). <b>B.</b> The multipotency of NSCs and GSCs. When induced into differentiation, both NSCs and GSCs gave rise to Tuj1+ neurons (green) and GFAP+ astrocytes (red). Representative images of NSC1 and GSC1 differentiation were shown. Nuclear Dapi staining was shown in blue. <b>C.</b> H&E staining of coronal sections from GSC-transplanted brains. The tumor region was indicated by an arrow, shown in dark purple color.</p
Background: The cancer stem cell (CSC) hypothesis posits that deregulated neural stem cells (NSCs) f...
<p>We seeded glioma cell line-derived GSs in methylcellulose-containing growth medium at an initial ...
This thesis is focused on neural stem cell (NSC) and glioma biology. I discuss how NSCs interact wit...
Neural stem cells (NSCs) are important multipotent adult stem cells capable of self-renewal and diff...
Glioblastoma multiforme is a severe form of cancer most likely arising from the transformation of st...
Transformed stem cells have been isolated from some human cancers. We report that, unlike other brai...
<p>(A) Representative photomicrograph of neurospheres in culture. (B) Immunocytochemical staining of...
Gliomas, in particular the high-grade anaplastic glioma and glioblastoma multiforme (GBM), are manif...
SummaryHuman brain tumors appear to have a hierarchical cellular organization suggestive of a stem c...
Glioblastoma multiforme (GBM) is the most common adult primary brain tumor and is comprised of a het...
Glioblastoma multiforme (GBM, WHO grade IV) is the most common and lethal subtype of primary brain t...
Cellular origin of glioblastoma (GB) is constantly discussed and remains a controversial subject. Un...
Abstract Background Although features of variable differentiation in glioblastoma cell cultures have...
<div><p>Photomicrographs (A–F) illustrate cases of neuronal (A and B), astrocytic (C and D), and oli...
Neural stem cells (NSCs) are self-renewing, multipotent cells in the embryonic or adult brain that c...
Background: The cancer stem cell (CSC) hypothesis posits that deregulated neural stem cells (NSCs) f...
<p>We seeded glioma cell line-derived GSs in methylcellulose-containing growth medium at an initial ...
This thesis is focused on neural stem cell (NSC) and glioma biology. I discuss how NSCs interact wit...
Neural stem cells (NSCs) are important multipotent adult stem cells capable of self-renewal and diff...
Glioblastoma multiforme is a severe form of cancer most likely arising from the transformation of st...
Transformed stem cells have been isolated from some human cancers. We report that, unlike other brai...
<p>(A) Representative photomicrograph of neurospheres in culture. (B) Immunocytochemical staining of...
Gliomas, in particular the high-grade anaplastic glioma and glioblastoma multiforme (GBM), are manif...
SummaryHuman brain tumors appear to have a hierarchical cellular organization suggestive of a stem c...
Glioblastoma multiforme (GBM) is the most common adult primary brain tumor and is comprised of a het...
Glioblastoma multiforme (GBM, WHO grade IV) is the most common and lethal subtype of primary brain t...
Cellular origin of glioblastoma (GB) is constantly discussed and remains a controversial subject. Un...
Abstract Background Although features of variable differentiation in glioblastoma cell cultures have...
<div><p>Photomicrographs (A–F) illustrate cases of neuronal (A and B), astrocytic (C and D), and oli...
Neural stem cells (NSCs) are self-renewing, multipotent cells in the embryonic or adult brain that c...
Background: The cancer stem cell (CSC) hypothesis posits that deregulated neural stem cells (NSCs) f...
<p>We seeded glioma cell line-derived GSs in methylcellulose-containing growth medium at an initial ...
This thesis is focused on neural stem cell (NSC) and glioma biology. I discuss how NSCs interact wit...