The D7H mutation enhances the neurotoxicity of Aβ42.
- Wei-Ting Chen (167673)
- Chen-Jee Hong (160996)
- Ya-Tzu Lin (167674)
- Wen-Han Chang (129553)
- He-Ting Huang (167675)
- Jhih-Ying Liao (167676)
- Yu-Jen Chang (167677)
- Yi-Fang Hsieh (167678)
- Chih-Ya Cheng (160978)
- Hsiu-Chih Liu (167679)
- Yun-Ru Chen (54058)
- Irene H. Cheng (167685)
Publication date
April 2012
DOIAbstract
<p>The neurotoxicities of Aβ42<sub>wt</sub> and Aβ42<sub>D7H</sub> were estimated by the MTT assay. SH-SY5Y cells were treated with Aβ42<sub>wt</sub> or Aβ42<sub>D7H</sub> at a final concentration of 0, 5, or 10 μM for 48 h. Cell survival was determined by normalizing OD570 readings to those of cells not treated with Aβ42 (set as 1) in 3 independent experiments (n = 8 per experiment) and is presented as mean ± SEM. ***<i>P</i><0.001, **<i>P</i><0.01 vs. Aβ42<sub>wt</sub> by ANOVA.</p
Add to ORKG