Brain regions ranked in order of decreasing regional efficiency in the (A) healthy control, (B) no HE, (C) MHE, and (C) OHE groups.

<p>The “hubs” were redistributed and the nodes that were 1 SD over the mean regional efficiency tended to be in the same regions of the association and primary cortices in each group. The HE groups had lower percentages of regional efficiency in the primary cortex for the HE (B, C, D) patients compared with the healthy controls. Each box plot shows the range for the individual estimates of the regional correlation strength values in each group. The boxes are color coded to differentiate the primary sensory or motor cortex (red), heteromodal association cortex (blue), limbic or paralimbic cortex (orange), and subcortical nuclei (green).