Putative ganoderic acid biosynthesis pathway in <i>G. lucidum</i>.

<p>Enzymes involved in this pathway are: AACT: acetyl-CoA acetyltransferase, [EC:2.3.1.9], K00626; HMGS: 3-hydroxy-3-methylglutaryl-CoA synthase, [EC:2.3.3.10], K01641; HMGR: 3-hydroxy-3-methylglutaryl-CoA reductase, [EC:1.1.1.34], K00021; MVK: mevalonate kinase, [EC:2.7.1.36], K00869; MPK: phosphomevalonate kinase, [EC:2.7.4.2], K00938; MVD: pyrophosphomevalonate decarboxylase, [EC:4.1.1.33], K01597; IDI: isopentenyl-diphosphate isomerase, [EC: 5.3.3.2], K01823; GPPs: geranyl diphosphate synthase, [EC: 2.5.1.1], K00787, K00804; FPPs: farnesyl diphosphate synthase, [EC: 2.5.1.10], K00787, K00804; SQS: squalene synthase, [EC: 2.5.1.21], K00801; SE: squalene monooxygenase, [EC: 1.14.99.7], K00511; OSC: 2, 3-oxidosqualene-lanosterol cyclase, [EC: 5.4.99.7], K01852; P450: cytochrome P450, [EC: 1.14.-.-]; UGTs: uridin diphosphate glycosyltransferases, [EC: 2.4.1.-]. Ingredients are in blue box. Limited enzymes are in red oval, key enzymes are in green oval while the other enzymes are in pink oval. Solid arrows and broken arrows represent single and putative multiple enzymatic steps respectively.