Snail1 and Snail2 recruit distinct co-repressors and may be modulated by distinct phosphorylation events.

<p>Schematic diagrams showing the structural domains of Snail2 (up) and Snail1 (bottom), indicating that the SNAG domain is involved in the recruitment of NCoR and mSin3A co-repressors in Snail2 and Snail1, respectively, while the Slug domain recruits CtBP1 in the case of Snail2. The regulatory phosphorylated serine residues identified in Snail2 in the present study and in Snail1 in a previous one <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0036132#pone.0036132-MacPherson1" target="_blank">[41]</a> are also shown with indication of the kinases involved in the case of Snail1.