Local and peripheral dynamics of innate and adaptive immune activation after hypoxic ischemic brain injury.

<p>(A) Temporal correlation of activated cells after HI brain injury. Note the 24 h and one week activation of CD11b⁺ cells as well as brain T-cell infiltration after one week. Black filled line; activated CD11b⁺CD86⁺ cells in the brain. Green short dashed line; activated CD8⁺CD69⁺ and blue long dashed line; CD4⁺CD69⁺ T-lymphocytes in the brain. Red dotted line; activated splenetic T-lymphocytes. Yellow long dashed line; Proportion CD86 expressing splenetic APCs. (B) Schematic overview of cellular inflammation after HI brain injury.