Clustered image map (CIM) of the relative expression of the 32 genes in <b>Figure 3</b> in each of the NCI-60 cell lines.

<p>In addition, the CIM includes CDH1 (E-cadherin, a marker genes for epithelial character) and VIM (vimentin, a marker genes for mesenchymal character). The CIM image (Euclidean norm, complete linkage) was computed using custom in-house R language code. The genes below the blue line are the 24 genes in high cross-correlation set HCCS24 (above the blue line in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0035716#pone-0035716-g003" target="_blank">Figure 3</a> and marked red in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0035716#pone-0035716-g011" target="_blank">Figures 11</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0035716#pone-0035716-g012" target="_blank">12</a> ). Genes that were also in HCCS15 (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0035716#pone-0035716-g002" target="_blank">Figure 2</a>) are highlighted in yellow. The vertical red lines help to discern which cell lines of a given tissue type cluster together, which deviate, and which fall into a cluster dominated by a different tissue type. The arrow points to ovarian carcinoma cell line OVCAR4, which was unusual in showing high expression of both CDH1 and VCL.