Three types of hands/feet manifestations and malformed teeth.

<p>(A) Symmetrical deformities. Patient III-5: absence of 2nd–3rd fingers and 2nd–3rd toes. Hand radiography: absence of 2nd–3rd phalanges and fusions of the 1st–2nd and 3rd–4th metacarpale in both hands. Feet radiography: absence of 2nd–3rd phalanx and osseous fusion of 1st–2nd metatarsal bone. Left panel: spade-shaped central incisor and open bite. (B) Asymmetric deformities. Patient III-7: Syndactyly of 1st–2nd finger, absence of middle finger, syndactyly of 1st–2nd and 3rd–4th toes. Radiography: missing third phalanges and cutaneous syndactyly of 1st–2nd and 3rd–4th toes. Left panel: cone-shaped left maxillary lateral incisor. (C) Patient II-3: Hands or feet were undistinguished from normal controls. (D) Patient III-3: Absent right maxillary lateral incisor and malformed lingual fossa in the left maxillary lateral incisor.