Distribution of IgVH mutations in uninfected B cell subsets and derived LCLs.

<p>Histograms show the cumulative pattern of IgVH somatic mutations in naive (N), non-switched memory (NSM) and switched memory (SM) B cell subsets pre-infection and in their derived LCLs. Mutations were scored between codons 9–92 (according to the Kabat numbering system) with codons known to be SHM hotspots shown as filled bars Note that each mutated clonotypic sequence identified within an LCL only contributes once to the overall data.