Summary of single nucleotide variations and non-synonymous mutations in GD1, GD2 and HKNPC1 genomes.

<p>(A) Number of single nucleotide variants (SNVs) of HKNPC1, GD1, GD2 and AG876 with each genome compared against reference EBV. The orange region represents the 322 SNVs shared by GD1, GD2 and HKNPC1 with exclusion of those of AG876, whereas the blue region represents the 347 SNVs shared by GD2 and HKNPC1 with exclusion of those of AG876 and GD1. (B) Non-synonymous SNVs shared by GD1, GD2 and HKNPC1 were categorized by protein function based on the work of Tabouriech et al. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0036939#pone.0036939-Tarbouriech1" target="_blank">[2]</a>. (C) Non-synonymous SNVs shared by GD1, GD2 and HKNPC1 and those shared by GD2 and HKNPC1 were pooled together and categorized by function of the genes.