Summary of change in FGF2 dynamics upon sm27 binding

<p>. The representative structure of FGF2-sm27 complex is shown in grey. Dynamics variations are mapped on the FGF2 structure. Blu and red colors code for decreased and increased backbone motions upon inhibitor binding. A) NMR data: colored ribbon represents S2 variations, sticks describe slow conformational exchange variations (R₁rho) and spheres indicate residues affected by HSQC intensity changes upon sm27 binding. B) MD data: mean squared fluctuations differences of all pair wise distances between the apo and holo form. For clarity purposes the complex was superimposed to the X-ray structure of FGFR1-FGF1 dimer (PDB id: 1FQ9) and the FGFR1 regions making contacts with FGF2 are shown. The two FGFR1 units are shown as green and light green cartoons.