<p>A) Mdx mice received NTX with or without THI treatment. Muscles were harvested on day 5 post-injury, and whole muscle extracts were examined for total STAT3 (STAT3-T) and phosphorylated STAT3 (STAT3-P) protein levels. Actin is used as a loading control. B) STAT3 activation in SC-derived myoblasts treated <i>in vitro</i> with 10 µM S1PR1 (R1i), S1PR2 (R2i), and S1PR3 (R3i) antagonists. S1PR1 is used as a loading control, as its expression is invariant under these conditions. C) WT SC-derived primary myoblasts were treated with S1PR2 antagonist (JTE-013) or vehicle, and whole cell extracts were examined for STAT3 phosphorylation, total STAT3 and p21 and p27 protein levels. Actin is used as a loading control. D) SC-derived primary myoblasts...
<p>NTX injury was performed in WT C57BL/6 mice and SphK1 KO mice in the C57BL/6 background. Blood pl...
Muscles of older animals are more susceptible to injury and regenerate poorly, in part due to a pers...
Signal transducer and activator of transcription 3 (STAT3) signaling plays critical roles in regulat...
<p>SC-derived myoblasts were treated with indicated dose of: A) Rac1 inhibitor, or B) RhoA inhibitor...
Recent studies have shown that STAT3 negatively regulates the proliferation of muscle satellite cell...
Skeletal muscle regeneration is a complex process which is not yet completely understood. Evidence s...
Skeletal muscle regeneration is a complex process which is not yet completely understood. Evidence s...
<div><h3>Background</h3><p>Skeletal muscle regeneration is a complex process which is not yet comple...
<p>A) Treatment of WT mice with THI for 2 days (2D) or 5 days (5D) results in elevated muscle S1P le...
(A) Tamoxifen-treated control (SOCS3fl/fl Pax7-CreER-) and SOCS3 MscKO (SOCS3fl/fl Pax7-CreER+) mice...
Tamoxifen-treated control (SOCS3fl/fl Pax7-CreER-) and SOCS3 MKO (SOCS3fl/fl Pax7-CreER+) mice were ...
SummaryRecent studies have shown that STAT3 negatively regulates the proliferation of muscle satelli...
Tamoxifen-treated control (SOCS3fl/fl Pax7-CreER-) and SOCS3 MKO (SOCS3fl/fl Pax7-CreER+) mice were ...
Oncostatin M (OSM) is a cytokine of the interleukin-6 family and plays importantroles during inflamm...
BACKGROUND: Muscles of old animals are injured more easily and regenerate poorly, attributed in part...
<p>NTX injury was performed in WT C57BL/6 mice and SphK1 KO mice in the C57BL/6 background. Blood pl...
Muscles of older animals are more susceptible to injury and regenerate poorly, in part due to a pers...
Signal transducer and activator of transcription 3 (STAT3) signaling plays critical roles in regulat...
<p>SC-derived myoblasts were treated with indicated dose of: A) Rac1 inhibitor, or B) RhoA inhibitor...
Recent studies have shown that STAT3 negatively regulates the proliferation of muscle satellite cell...
Skeletal muscle regeneration is a complex process which is not yet completely understood. Evidence s...
Skeletal muscle regeneration is a complex process which is not yet completely understood. Evidence s...
<div><h3>Background</h3><p>Skeletal muscle regeneration is a complex process which is not yet comple...
<p>A) Treatment of WT mice with THI for 2 days (2D) or 5 days (5D) results in elevated muscle S1P le...
(A) Tamoxifen-treated control (SOCS3fl/fl Pax7-CreER-) and SOCS3 MscKO (SOCS3fl/fl Pax7-CreER+) mice...
Tamoxifen-treated control (SOCS3fl/fl Pax7-CreER-) and SOCS3 MKO (SOCS3fl/fl Pax7-CreER+) mice were ...
SummaryRecent studies have shown that STAT3 negatively regulates the proliferation of muscle satelli...
Tamoxifen-treated control (SOCS3fl/fl Pax7-CreER-) and SOCS3 MKO (SOCS3fl/fl Pax7-CreER+) mice were ...
Oncostatin M (OSM) is a cytokine of the interleukin-6 family and plays importantroles during inflamm...
BACKGROUND: Muscles of old animals are injured more easily and regenerate poorly, attributed in part...
<p>NTX injury was performed in WT C57BL/6 mice and SphK1 KO mice in the C57BL/6 background. Blood pl...
Muscles of older animals are more susceptible to injury and regenerate poorly, in part due to a pers...
Signal transducer and activator of transcription 3 (STAT3) signaling plays critical roles in regulat...