Wt mice are as susceptible as <i>Ifit2^−/−</i> mice to intracranial VSV infection.

<p><b>A</b>, survival of wt and <i>Ifit2^−/−</i> mice after intracranial injection of 10 pfu of VSV; cumulative data from three independent experiments. <b>B</b>, infectious VSV titers in wt and <i>Ifit2</i>^−/− brains at 24 and 48 hours after intracranial injection of 10 pfu of VSV; plotted as pfu/g with mean on log scale; dashed line depicts threshold of detection; n = 7 mice per infected group from two independent experiments; n.s.: not significant. <b>C</b>, <i>Ifit2</i>, <i>Ifit1</i>, <i>IFN-β</i> and <i>VSV-N</i> RNA levels in brains of intracranially VSV-infected or PBS-injected wt and <i>Ifit2</i>^−/− mice at 24 hours p.i., plotted as mean+SD, VSV RNA levels plotted on log scale; n = 3 mice per infected group; ND, none detected.