Unlike the brain, other organs of <i>Ifit2^−/−</i> mice are not more susceptible to intranasal VSV infection.

<p><b>A–C</b>, infectious VSV titers in organs of wt, <i>Ifit2</i>^−/− or <i>IFNAR</i>^−/− mice (n = 4–10 mice per group accumulated from three independent experiments) at 2, 4, 5 and 6 days after intranasal infection; livers (A), lungs (B) and brains (C, incl. OB) of the same mice were assayed and plotted as pfu/g with mean; not all available livers were titered. Dashed line depicts threshold of detection. <b>D/E</b>, <i>Ifit2</i>, <i>Ifit1</i>, <i>IFN-β</i> mRNA levels in livers (D) and lungs (E) of uninfected or VSV-infected wt mice at 2 d.p.i., plotted as mean+SD; n = 4 mice per infected group; ND, none detected. All infections were intranasal with 4×10² pfu of VSV. Asterisks indicate statistical significance: * p<0.05, ** p<0.005.