Confined FGF2 expression abrogates high-level FGF2-associated osteomalacia.

<p>(a) Representative illustration of Goldner's trichrome staining of femurs from each group. Green indicates mineralized bone and red or pink unmineralized bone. (b) Serum Fgf23 levels and relative <i>Fgf23</i> mRNA expression in femurs from the GFP control mice, the β-globin-FGF2 mice and the high SFFV-FGF2 mice. <i>P</i><0.001 for all comparisons. (c) Serum Fgf23 is positively correlated with serum FGF2 levels. <i>P</i><0.001. (d). Serum levels of PTH. <i>P</i><0.001 for all comparisons. (e) Serum phosphate levels. GFP control vs. β-globin-FGF2, <i>P</i> = 0.06; <i>P</i><0.001 for all the other comparisons. (f) Serum calcium levels. GFP control vs. β-globin-FGF2, <i>P</i> = 0.40; <i>P</i><0.01 for all the other comparisons. Data shown are presented as mean ± SEM (n = 10 mice/group).