Quantitative analysis of the collagen fibers in the subcutaneous pancreatic tumor xenografts.

<p>(A) The collagen density decreases as the tumor xenografts grow. The density of the tumors at 5 days is significantly higher in comparison to those at 20 days (*, p = 0.033, ANOVA linear contrast) and 30 days (**, p = 0.005, ANOVA linear contrast). +, outliers on the box-and-whisker diagram; <i>bars</i>, total extent of the data. (B) The organization of collagen fibers changes during the growth of the subcutaneous pancreatic tumor xenografts. An overall comparison of the correlation values shows the greatest difference between the tumor xenografts harvested at 5 days and those harvested after 10 days, as indicated by the Corr₅₀ value, the distance where the correlation crossed 50% of the initial correlation. *, p = 0.035, ANOVA linear contrast. The sample size is 5 for each group (5 mice). Error bars are one standard deviation above and below each data point.