Non-synonymous mutations identified for HCV NS5A Δ414-428 deletion mutants.

A<p>Numbering is according to individual H77 reference proteins (AF009606). Numbering according to the H77 reference polyprotein is given in parenthesis. All original cell culture adaptive mutations, as indicated in Materials & Methods, and the engineered deletion were retained. Mutations in the ORF are listed for residues with at least 50% change in the sequence reads. No changes were observed for Δ414-428 mutants of other NS5A isolates.