<p>(A)–(D) WST-8 assay showing the sensitivity of endometrial cancer cells to NVP-BEZ235 and RAD001 at increasing concentrations of drug (nmol/L) for 72 h. The data was normalized to the value of control cells. (A) Four group A cell lines with double mutations of <i>PIK3CA</i> and <i>PTEN</i>, (B) Five group B cell lines with <i>PTEN</i> mutations, (C) Two group C cell lines with coexistent mutations of <i>K-Ras</i> and <i>PIK3CA</i>, and (D) Two group D cell lines with chromosomal copy number amplification at the locus of <i>K-Ras</i>. All experiments were repeated 3 times, and each value is shown as the mean of 3 experiments ± S.D.</p
<p>RT112 and T24 cells were treated with RAD001 (5 nM), NVP-BEZ235 (100 nM for T24, 500 nM for RT112...
Endometrial carcinoma (EC) is the most common gynecological cancer in the Western World. Treatment o...
<p>SK-BR-3 cells were treated with RAD001 and/or BEZ235 at the indicated concentrations and electric...
The PI3K (phosphatidylinositol-3-kinase)/mTOR (mammalian target of rapamycin) pathway is frequently ...
<p><b><i>K-Ras</i></b><b> (mutation or amplification).</b> (A)–(B) WST-8 assay was performed in HEC-...
<p>(A–D) Cells (5×10<sup>5</sup>) were seeded in the presence of 10% serum and treated with NVP-BEZ2...
<p>A, Western blot demonstrating the expression status of MRE11, NBS1 and RAD50 in 10 endometrial ca...
Objectives. Endometrial carcinoma (EC) is the most common gynecological cancer in the Western World....
<p>(A) Inhibitory effects of NVP-BEZ235 on NPC cells and normal nasopharyngeal cells. Cells were cul...
The PI3K (phosphatidylinositol-3-kinase)/mTOR (mammalian target of rapamycin) pathway is frequently ...
Endometrial carcinoma (EC) is the most common gynecological cancer in the Western World. Treatment o...
Abstract Background Phosphatase and Tensin homolog (PTEN) is a tumor suppressor gene. Loss of its fu...
<p>(A) Cell viability of mutant and wild-type isogenic <i>PIK3CA</i> cells was assessed by MTS assay...
<p><b>A, B</b>: Basal cell proliferation in non-treated epithelial (A) and stromal (B) cells of endo...
<p>A,B: HMC-1.1 cells (left panels), HMC-1.2 cells (middle panels), and KU812 cells (right panels) w...
<p>RT112 and T24 cells were treated with RAD001 (5 nM), NVP-BEZ235 (100 nM for T24, 500 nM for RT112...
Endometrial carcinoma (EC) is the most common gynecological cancer in the Western World. Treatment o...
<p>SK-BR-3 cells were treated with RAD001 and/or BEZ235 at the indicated concentrations and electric...
The PI3K (phosphatidylinositol-3-kinase)/mTOR (mammalian target of rapamycin) pathway is frequently ...
<p><b><i>K-Ras</i></b><b> (mutation or amplification).</b> (A)–(B) WST-8 assay was performed in HEC-...
<p>(A–D) Cells (5×10<sup>5</sup>) were seeded in the presence of 10% serum and treated with NVP-BEZ2...
<p>A, Western blot demonstrating the expression status of MRE11, NBS1 and RAD50 in 10 endometrial ca...
Objectives. Endometrial carcinoma (EC) is the most common gynecological cancer in the Western World....
<p>(A) Inhibitory effects of NVP-BEZ235 on NPC cells and normal nasopharyngeal cells. Cells were cul...
The PI3K (phosphatidylinositol-3-kinase)/mTOR (mammalian target of rapamycin) pathway is frequently ...
Endometrial carcinoma (EC) is the most common gynecological cancer in the Western World. Treatment o...
Abstract Background Phosphatase and Tensin homolog (PTEN) is a tumor suppressor gene. Loss of its fu...
<p>(A) Cell viability of mutant and wild-type isogenic <i>PIK3CA</i> cells was assessed by MTS assay...
<p><b>A, B</b>: Basal cell proliferation in non-treated epithelial (A) and stromal (B) cells of endo...
<p>A,B: HMC-1.1 cells (left panels), HMC-1.2 cells (middle panels), and KU812 cells (right panels) w...
<p>RT112 and T24 cells were treated with RAD001 (5 nM), NVP-BEZ235 (100 nM for T24, 500 nM for RT112...
Endometrial carcinoma (EC) is the most common gynecological cancer in the Western World. Treatment o...
<p>SK-BR-3 cells were treated with RAD001 and/or BEZ235 at the indicated concentrations and electric...