<p>Squares represent male family members, circles female, and diamonds sex unknown. Numbers inside diamonds show the number of siblings. Black and grey symbols represent persons with diabetes and impaired glucose tolerance, respectively. An arrow denotes the proband in each family and stars indicate those subjects for whom DNA was available. Data under the symbols represent from top to bottom: age at diabetes diagnosis, mutation carrier status (N = Normal allele, M = Mutation), BMI and treatment (INS = Insulin, OHA = Oral Hypoglycemic Agents).</p
<p>Genetic analyses were performed on all individuals indicated by filled, divided and open symbols....
<p>Clinically affected individuals are indicated with shaded symbols. Individuals for whom DNA sampl...
<p>(N, Normal allele; M, mutation). Solid black-filled shapes represent patients with permanent neon...
<p>With regard to the genetic status, NM denotes the presence of the heterozygous <i>KCNJ11</i> p.Gl...
<p>(A) Three siblings presented with young onset diabetes and microcephaly with intellectual disabil...
<p>Individuals from whom DNA was available are assigned the DNA notation in small lettering to the t...
DNA was available for all numbered individuals depicted by a diamond with a central dot. Exome seque...
<p>Circles and squares represent females and males, respectively. Clear symbols represent unaffected...
<p>Below the individuals, genotypes are presented for either p.S1653KfsX2 (M1), p.L2784R (M2), p.Y29...
<p>Black symbols indicate that the person has IFG, IGT or T2D (squares = men, circles = females), wh...
<p>The proband is marked with an arrow. Black symbols indicate clinically affected family members, o...
The pedigree is abbreviated to increase readability and to protect the family from identification. H...
<p>The black squares reflect affected males. Circles with a dot represent unaffected heterozygous fe...
<p>Filled symbols indicate family members with either <i>systemic mastocytosis</i> (<i>SM</i>), acco...
<p>The family history reveals 22 affected members in 4 generations. The dark symbols represent the a...
<p>Genetic analyses were performed on all individuals indicated by filled, divided and open symbols....
<p>Clinically affected individuals are indicated with shaded symbols. Individuals for whom DNA sampl...
<p>(N, Normal allele; M, mutation). Solid black-filled shapes represent patients with permanent neon...
<p>With regard to the genetic status, NM denotes the presence of the heterozygous <i>KCNJ11</i> p.Gl...
<p>(A) Three siblings presented with young onset diabetes and microcephaly with intellectual disabil...
<p>Individuals from whom DNA was available are assigned the DNA notation in small lettering to the t...
DNA was available for all numbered individuals depicted by a diamond with a central dot. Exome seque...
<p>Circles and squares represent females and males, respectively. Clear symbols represent unaffected...
<p>Below the individuals, genotypes are presented for either p.S1653KfsX2 (M1), p.L2784R (M2), p.Y29...
<p>Black symbols indicate that the person has IFG, IGT or T2D (squares = men, circles = females), wh...
<p>The proband is marked with an arrow. Black symbols indicate clinically affected family members, o...
The pedigree is abbreviated to increase readability and to protect the family from identification. H...
<p>The black squares reflect affected males. Circles with a dot represent unaffected heterozygous fe...
<p>Filled symbols indicate family members with either <i>systemic mastocytosis</i> (<i>SM</i>), acco...
<p>The family history reveals 22 affected members in 4 generations. The dark symbols represent the a...
<p>Genetic analyses were performed on all individuals indicated by filled, divided and open symbols....
<p>Clinically affected individuals are indicated with shaded symbols. Individuals for whom DNA sampl...
<p>(N, Normal allele; M, mutation). Solid black-filled shapes represent patients with permanent neon...