A sucrose-rich (SR) diet normalizes elevated CYP7A1 levels and induces the expression of the metabolic regulators FGF15 and FGF21 in <i>Slc10a2</i>−/− mice.

<p>Livers from wt and <i>Slc10a2</i>−/− mice fed regular chow or a SR diet were analysed for A), mRNA levels of Cyp7a1; B), Serum C4 levels, a marker of Cyp7a1 enzymatic activity; C), hepatic mRNA levels of SHP; and for D), HMGCoA synthase, HMGCoA reductase and SREBP2 mRNA. In panel E, FGF15, SHP and IBABP mRNA levels were determined in samples from distal ileum of wt and <i>Slc10a2</i>−/− mice fed regular diet or the SR diet. Data are expressed as mean ± standard error (SEM), n = 5–6. mRNA expression for the wt group on regular chow is normalized to 1. Significances of differences between groups were tested by Student’s t test, a p-value <0.05 is denoted *. p<0.01 is denoted **.