Model of regulation of <i>Igf2</i> transcription by <i>91H</i> and <i>H19</i> RNAs in myoblastic cells.

<p>This model is based on the three critical parameters that we have quantified in this work: the <i>Igf2</i> transcription levels, the <i>91H</i> and <i>H19</i> steady state RNA levels. <i>91H</i> and <i>H19</i> RNAs are direct and/or indirect antagonists riboregulators of <i>Igf2</i> transcription. H19 appears as having a negative effect on <i>Igf2</i> transcription while <i>91H</i> RNA has an opposite effect. Interestingly, <i>91H</i> RNA stimulates a new <i>Igf2</i> promoter (Pm) located within the <i>Igf2</i> Differentially Methylated Region 1 (DMR1).