Survival curve, body weight and bacterial loads in lung and liver of mice infected with 10⁷CFU of <i>M. bovis</i> BCG.

<p>(A) Long-term survival of mice infected with living <i>M. bovis</i> BCG Connaught (10⁷). (B) Body weight change after <i>M. bovis</i> BCG infection. Wild-type and memTNF^Δ1–9,K11E KI, (<i>n</i> = 14 mice per group), memTNF^Δ1–12 (<i>n</i> = 10 mice), and TNF−/− mice (<i>n</i> = 6 per group). Data from two representative experiments are shown. CFU were determined in lungs (C, D) and liver (E, F) at 2 and 4 weeks after infection with 10⁷ CFU of <i>M. bovis</i> BCG. Data are represented as individual values and horizontal bars indicate mean (<i>n</i> = 4–6 mice per group). Asterisks indicate statistically significant differences between wild type and indicated group (*, p<0.03).