Breadth and magnitude of T cell responses against HIV peptides.

<p>(A) To evaluate T cell response breadth, PBMC from different patient groups were stimulated with peptide pools spanning the whole HIV genome. In the Y-axis the number of pools tested for each gene or gene group is indicated. In the X-axis the mean number (+SD) of peptide pools inducing positive ELISPOT responses in the HAART, TN, SNC, EC and SC patient groups is represented. (B) Based on the same dataset, the magnitude of the response was calculated as the mean number of IFN-γ spot forming cells (SFC) per million PBMC for each group of patients. Only peptide pools against which a positive response was measured, were included in this calculation. For each patient the SFC of positive peptide pools within each protein were cumulated and the mean (+SD) within each patient group is represented. No statistical differences were found.