Schematic of the role of laminin-511 in intestinal tissue homeostasis.
- Léa Ritié (161318)
- Caroline Spenlé (161321)
- Joël Lacroute (161324)
- Anne-Laure Bolcato-Bellemin (161326)
- Olivier Lefebvre (161329)
- Christine Bole-Feysot (182)
- Bernard Jost (18625)
- Annick Klein (161337)
- Christiane Arnold (161340)
- Michèle Kedinger (161348)
- Dominique Bagnard (161355)
- Gertraud Orend (161362)
- Patricia Simon-Assmann (161372)
Publication date
May 2012
DOIAbstract
<p>Laminin-511 is deposited in the intestine by both epithelial and mesenchymal cells <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0037710#pone.0037710-Lefebvre1" target="_blank">[11]</a>. Its absence (KO model or RNA knockdown experiments) or presence (<i>in vitro</i> assays) leads to activation or inactivation of Wnt and PI3Kinase signaling pathways promoting multiple cellular responses that impact on survival, migration and differentiation.</p
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