GLD-1 and CGH-1 co-regulated mRNAs accumulate in oocytes.

<p>(A) The expression patterns of GBM<i>wt</i> and GBM<i>mut</i> reporters as determined by in situ hybridization against <i>gfp</i> RNA. Wild-type gonads, not expressing a GFP reporter, were negative. Oocytes are indicated with brackets. (B) Model of how GLD-1 and CGH-1 mediated mRNA stabilization may lead to mRNA accumulation in oocytes. The blue lines indicate a general influx of the cytoplasm from undifferentiated germ cells to oocytes as reported by Wolke et al, 2007. GLD-1 and CGH-1 mediated protection in the medial part ensures that mRNAs are transported into oocytes (top). In the absence of this protection, mRNAs are degraded by an unknown mechanism(s) and thus fail to accumulate in oocytes.